Amikacin (Draft)
====================

**PD Dialyzability**: Likely

Pharmacokinetic Parameters  [1]_ [2]_ [3]_ [4]_
---------------------------

======= ======
/////// |pk|
======= ======
|pk1|   |v1|
|pk2|   |v2|
|pk3|   |v3|
|pk4|   |v4|
|pk5|   |v5|
|pk6|   |v6|
|pk7|   |v7|
======= ====== 

.. |pk| replace:: Amikacin
.. |pk1| replace:: Molecular Weight (Da)  
.. |pk2| replace:: Plasma Protein Binding (%)
.. |pk3| replace:: Volume of Distribution (L/Kg) 
.. |pk4| replace:: Hepatic Metabolism 
.. |pk5| replace:: Excreted Unchanged (%) 
.. |pk6| replace:: Half-Life; Normal Renal Function (hours)
.. |pk7| replace:: Half-Life; ESRD (hours) 
.. |v1| replace:: 586
.. |v2| replace:: <5
.. |v3| replace:: 0.22-0.29
.. |v4| replace:: Mostly excreted renally unchanged
.. |v5| replace:: 95
.. |v6| replace:: 1.4-2.3
.. |v7| replace:: 17-150

References
------------

.. [1] Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, et al. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-672. 

.. [2] American Pharmacists Association. Drug information handbook: a comprehensive resource for all clinicians and healthcare professionals. Hudson, Ohio; [Washington, D.C.: Lexi-Comp ; American Pharmacists Association; 2012. 

.. [3] Aronoff GR, editor. Drug prescribing in renal failure: dosing guidelines for adults and children. 5. ed. Philadelphia, Pa: American College of Physicians; 2007. 

.. [4] Gilbert B, Robbins P, Livornese LL. Use of Antibacterial Agents in Renal Failure. Medical Clinics of North America. 2011 Jul;95(4):677–702.